Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung J. Structure-based Development of a Sirtuin 2 Affinity Probe Angew Chem Int Ed Engl 54, 1 – 6 (2015) More info >>>

Sándor Szunyogh, Judit Oláh, Tibor Szénási, Adél Szabó, Judit Ovádi Targeting the interface of the pathological complex of α-synuclein and TPPP/p25 Bioche Biophys Acta_Mol Basis Disease ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: pp. 2653-2661. (2015) More info >>>

Schiedel,M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Aminothiazoles as potent and selective Sirt2 inhibitors – a structure-activity relationship study J Med Chem (2016) DOI: 10.1021/acs.jmedchem.5b01517 More info >>>

Zwick V, Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, Ovadi J, Cuendet M, Blanquart C, Bertrand P. Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. Bioorg Med Chem Lett. 26:154-159 (2016) More info >>>

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Olah J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovadi J, Schutkowski M, Sippl W, Einsle O, Jung M. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site NATURE COMMUNICATIONS 6: p. 6263. (2015) More […]