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Drosophila. Developmental Epigenetics

abusturia@cbm.csic.es
www.cbm.uam.es/joomla-rl/index.php/en/scientific-departments/developmet-and-differentiation?id=%20730
Address
Centro de Biología Molecular. c)Nicolas Cabrera 1, 28049 Madrid, Spain
Spain
Keywords

Drosophila development, epigenetic, Polycomb/ trithorax, microRNAs, apoptosis

Models

Drosophila, imaginal discs, intestine, S2 cells.

Techniques

Classical genetics, Molecular Genetics, Standard molecular biology and biochemistry. FACS . Confocal microscopy

Collaborations outside COST

In the last years, my lab has collaborated with Dr. P. Verrijzer, (Erasmus Medical Center, Rotterdam, The Netherlands) for proteomics and histone and protein biochemistry; with Dr. G. Cavalli (Institute of Human Genetics, Montpellier, France) for Chip-seq analysis; with Dr. B.Lemaitre (Global Health Institute, EPFL, Lausanne, Switzerland) for innate immune response analysis and with Dr. S.Bray (Cambridge University, UK) for Notch function studies.

Short description of ongoing research projects

We investigate: 1-The epigenetic contribution to normal and pathological development using Drosophila imaginal discs and the adult Drosophila intestine. 2- The dP53 stabilization mechanisms. 3- The regulation of Polycomb and trithorax protein levels mediated by microRNAs.

Publications
  1. Aparicio, R, Simoes da Silva, C., Busturia A (2015) .The microRNA mir-7 contributes to the control of Drosophila wing growth.: Developmental Dynamics; 244(1):21-30
  2. Fereres, S., Simón, R., Mohd-Sarip, A., Verrijzer, CP., Busturia, A (2014). dRYBP counteracts chromatin-dependent activation and repression of transcription. PLoS One Nov 21;9(11):e113255.
  3. Simón, R., Aparicio, R., Houdsen, B., Bray, S., Busturia, A (2014) Drosophila p53 controls Notch expression and balances apoptosis and proliferation. Apoptosis 19 (10), 1430-43.
  4. Fereres,S., Simón, R, Busturia, A (2013). A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila. Apoptosis18, (12), 1500 -1512
  5. Aparicio, R., Neyen,C., Lemaitre, B., Busturia, A. (2013) dRYBP contributes to the negative regulation of Drosophila IMD pathway. PloS One, Apr 15:8 (4): e62052
Other activities of potential interest to others


Cost UE