Jung group, Chemical epigenetics

Address

Keywords

chemical epigenetics, medicinal chemistry, inhibitors, assays, screening

Models

cell culture, isolated enyzmes

Techniques

in-vitro biochemistry, medicinal chemistry, cellular target engagement

Collaborations outside COST

Structural genomics consortium

Short description of ongoing research projects

Development of assays and inhibitors for histone modifying enzymes (HDACs, sirtuins, HATs, demethylases) and reader proteins

Publications

1. Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. T. Wagner, H. Greschik, T. Burgahn, K. Schmidtkunz, A. K. Schott, J. McMillan, L. Baranauskiené, Y. Xiong, O. Fedorov, J. Jin, U. Oppermann, D. Matulis, R. Schüle, M. Jung; Nucleic Acids Res., (2016) accepted.
2. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. E. Metzger, D. Willmann, J. McMillan, I. Forne, P. Metzger, S. Gerhardt, K. Petroll, A. von Maessenhausen, S. Urban, A.-K. Schott, A. Espejo, A. Eberlin, D. Wohlwend, K. M. Schüle, M. Schleicher, S. Perner, M. T. Bedford, M. Jung, J. Dengjel, R. Flaig, A. Imhof, O. Einsle, R. Schüle; Nat. Struct. Mol. Biol. 23 (2016) 132-139
3. tructure-Based Development of an Affinity Probe for Sirtuin 2. M. Schiedel, T. Rumpf, B. Karaman, A. Lehotzky, S. Gerhardt, J. Ovádi, W. Sippl, O. Einsle, M. Jung; Angew. Chem. Int. Ed. 55 (2016) 2252-2256
4. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. T. Rumpf, M. Schiedel, B. Karaman, C. Roessler, B. J. North, A. Lehotzky, J. Oláh, K. I. Ladwein, K. Schmidtkunz, M. Gajer, M. Pannek, C. Steegborn, D. A. Sinclair, S. Gerhardt, J. Ovádi, M. Schutkowski, W. Sippl, O. Einsle, M. Jung; Nat. Commun. 6 (2015) 6263
5. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. J. M. Gajer, S. D. Furdas, A. Gründer, M. Gothwal, U. Heinicke, K. Keller, F. Colland, S. Fulda, H. L. Pahl, I. Fichtner, W. Sippl, M. Jung; Oncogenesis 4 (2015) e137

Other activities of potential interest to others