Address
Institut für Pharmazeutische Wissenschaften Albert-Ludwigs-Universität Freiburg Albertstraße 25 79104 Freiburg i.Br.GermanyKeywords
chemical epigenetics, medicinal chemistry, inhibitors, assays, screening
Models
cell culture, isolated enyzmes
Techniques
in-vitro biochemistry, medicinal chemistry, cellular target engagement
Collaborations outside COST
Structural genomics consortium
Short description of ongoing research projects
Development of assays and inhibitors for histone modifying enzymes (HDACs, sirtuins, HATs, demethylases) and reader proteins
Publications
- Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.
T. Wagner, H. Greschik, T. Burgahn, K. Schmidtkunz, A. K. Schott, J. McMillan, L. Baranauskiené, Y. Xiong, O. Fedorov, J. Jin, U. Oppermann, D. Matulis, R. Schüle, M. Jung; Nucleic Acids Res., (2016) accepted.
- Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
E. Metzger, D. Willmann, J. McMillan, I. Forne, P. Metzger, S. Gerhardt, K. Petroll, A. von Maessenhausen, S. Urban, A.-K. Schott, A. Espejo, A. Eberlin, D. Wohlwend, K. M. Schüle, M. Schleicher, S. Perner, M. T. Bedford, M. Jung, J. Dengjel, R. Flaig, A. Imhof, O. Einsle, R. Schüle; Nat. Struct. Mol. Biol. 23 (2016) 132-139
- tructure-Based Development of an Affinity Probe for Sirtuin 2.
M. Schiedel, T. Rumpf, B. Karaman, A. Lehotzky, S. Gerhardt, J. Ovádi, W. Sippl, O. Einsle, M. Jung; Angew. Chem. Int. Ed. 55 (2016) 2252-2256
- Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
T. Rumpf, M. Schiedel, B. Karaman, C. Roessler, B. J. North, A. Lehotzky, J. Oláh, K. I. Ladwein, K. Schmidtkunz, M. Gajer, M. Pannek, C. Steegborn, D. A. Sinclair, S. Gerhardt, J. Ovádi, M. Schutkowski, W. Sippl, O. Einsle, M. Jung; Nat. Commun. 6 (2015) 6263
- Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo.
J. M. Gajer, S. D. Furdas, A. Gründer, M. Gothwal, U. Heinicke, K. Keller, F. Colland, S. Fulda, H. L. Pahl, I. Fichtner, W. Sippl, M. Jung; Oncogenesis 4 (2015) e137
Other activities of potential interest to others