info@epichembio.eu + 34 986 812 316

Immune Endocrine Epigenetics Research Group

jonathan.turner@lih.lu
www.lih.lu/page/departments/dii-all6-immune-endocrine-and-epigenetics-1385
Address
29, rue Henri Koch L-4354 Esch-sur-Alzette LUXEMBOURG
Luxembourg
Keywords

methylation; HPA-Axis; clinical; pre-clinical, Behavioural epigenetics, DNA methylation, glucocorticoid receptor, stress response

Models

cell lines, early life immune programming (mice), restraint stress (mice, rats) chronic social stress (mice and rats), Psychosocial stress e.g. TSST, seCPT in humans, human cohorts e.g. early life adversity (post-institutionalisation)

Techniques

Methyl-Seq MeDIP-Seq Pyrosequencing Clinical cohorts

Collaborations outside COST

Uni. Trier (Germany) LACDR (NL) Uni. Luxembourg (LU) Uni Bergen (NO)

Short description of ongoing research projects

EpiPath – Severe childhood adversity is thought to be one of the strongest risk factors for three major public health problems: cardiovascular disease, upper respiratory tract infections (URTI) and mental health problems. The principal interface between the environment and the genome is epigenetic methylation of genomic DNA. Our working hypothesis is that early life adversity induces high risk epigenetic modifications, and a cohort of young adults that experienced poor early life conditions are currently being recruited.

Publications
  1. Kirschner SA Hunewald O Meriaux SB Brunnhoefer R Muller CP Turner JD (2016) Focussing reduced representation CpG sequencing through judicious restriction enzyme choice. Genomics.107(4):109-19.
  2. Leenen FA Vernocchi S Hunewald OE Schmitz S Molitor AM Muller CP Turner JD. (2016) Where does transcription start? 5'-RACE adapted to next-generation sequencing. Nucleic Acids Res. 44(6):2628-45.
  3. Li-Tempel T, Larra MF, Sandt E, Mériaux SB, Schote AB, Schächinger H, Muller CP, Turner JD (2016) The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation Clinical Epigenetics 8: 1. 12.
  4. Vinkers CH , Kalafateli AL, Rutten BPF, Kas MJ, Kaminsky Z, Turner JD, Boks MPM (2015) Traumatic stress and human DNA methylation: a critical review Epigenomics 7: 5. 593-608.
  5. Turner JD, Vernocchi S, Schmitz S, Muller CP (2014) Role of the 5'-untranslated regions in post-transcriptional regulation of the human Glucocorticoid Receptor BBA Gene Regulatory Mechanisms 1839: 11. 1051-1061.
Other activities of potential interest to others


Cost UE