Address
Dep. of Gene Regulation. Bulgarian Academy of Sciences. Acad. G. Bonchev str., bl. 21. 1113 Sofia. BulgariaBulgariaKeywords
gene regulation, gene and protein modifications, epigenomics, DNA glycation and repair
Models
Escherichia coli and mammalian cells
Techniques
Recombinant DNA technology, LC-ESI/MS, HPLC, immunologic techniques (ELISA, blotting).
Collaborations outside COST
Purdue University, West Lafayette, IN, US, Harvard University, Boston, MA, USA and Nagoya University Graduate School of Medicine, Nagoya, Japan
Short description of ongoing research projects
1. Glycation and immunogenicity of protein therapeutics
2. Anti-glycation activity of vitamin B6
3. Repair of glycation damaged DNA
Publications
- Bozhinov A, Handzhiyski Y, Genov K, Daskalovska V, Niwa T, Ivanov I, Mironova R. Advanced glycation end products contribute to the immunogenicity of IFN-β pharmaceuticals. J Allergy Clin Immunol. 2012 Mar;129(3):855-858.
- Mironova R, Handzhiyski Y, Niwa T, Berzal-Herranz A, Datsenko KA, Wanner BL, Ivanov I. Maillard Reaction and Spontaneous Mutagenesis in Escherichia coli. Chapter 1 in: Encyclopedia of DNA Research (3 Volume set), Eds: Duncan SJ and Wiley PH, Nova Science Publishers, Inc. NY, USA (2012-February) рр 51-88, ISBN 978-1-61324-305-3.
- Mironova R, Niwa T, Handzhiyski Y, Sredovska A, Ivanov I. Evidence for non-enzymatic glycosylation of Escherichia coli chromosomal DNA. Mol Microbiol. 2005 Mar;55(6):1801-1811.
- Mironova R, Niwa T, Dimitrova R, Boyanova M, Ivanov I. Glycation and post-translational processing of human interferon-gamma expressed in Escherichia coli. J Biol Chem. 2003 Dec 19;278(51):51068-1074.
- Mironova R, Niwa T, Hayashi H, Dimitrova R, Ivanov I. Evidence for non-enzymatic glycosylation in Escherichia coli. Mol Microbiol.
Other activities of potential interest to others
Head of Mass-spectrometry laboratory. (MC Substitute)
