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Bonger Lab: Biomolecular chemistry
Radboud University, HG03.018, Heyendaalseweg 135, 6525AJ

Chemical biology, chemoenzymatic proximity labeling, chemical proteomics, bioorthogonal chemistry, targeted drug delivery



bioorthogonal chemistry, organic synthesis, proximity labeling, molecular biology

Collaborations outside COST

COST Action CM1004: Chemistry and Molecular Sciences and Technologies (CMST)

Short description of ongoing research projects

My research group is in the field of chemical biology and medicinal chemistry and we are sandwiched between the Radboud University and the Radboud Institute for Molecular Life Sciences. We combine organic chemistry with molecular biology and biochemistry to target and answer biological questions related to autoimmune- and protein misfolding diseases. My research is involved in the development of small molecule probes and engineered biological systems to specifically visualize, modulate and understand processes on a subcellular level and that are involved in cellular protein quality control. In addition we develop novel strategies to target and eliminate misfolded protein structures. To avoid any undesirable off-target effects, we are developing cell-type specific systems that are activated only in the presence of specific triggers. As such, a two-step small-molecule based clearance strategy will ensure that degradation is selective in cells that contain protein aggregates while healthy aggregate-free cells are not affected.

  1. Selma Eising, Francis Lelivelt, Kimberly M. Bonger*. Vinylboronic Acids as Fast Reacting, Synthetically Accessible, and Stable Bioorthogonal Reactants in the Carboni–Lindsey Reaction. Angew. Chem. Int. Ed. 2016, 55, 12243-12247.
  2. Sean R. Collins, Hee W. Yang, Kimberly M. Bonger, Emmanuel G. Guignet, Thomas J. Wandless and Tobias Meyer. Using light to shape chemical gradients for parallel and automated analysis of chemotaxis. Mol. Sys. Biol. 2015, 11, 804.
  3. Kimberly M. Bonger*, Rishi Rakhit, Alexander Y. Payumo, James K. Chen, Thomas J. Wandless*. A general method for regulating protein stability by light. ACS Chem. Biol. 2014, 9, 111-115.
  4. Kimberly M. Bonger, Ling-chun Chen, Corey W. Liu and Thomas J. Wandless. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat. Chem. Biol. 2011, 7, 531-537. 
  5. Kimberly M. Bonger, Varsha V.Kapoerchan, Gijsbert M Grotenbreg, Chris J. van Koppen, C. Marco Timmers, Gijsbert A van der Marel, Herman S. Overkleeft. Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands. Org. Biomol. Chem. 2010, 8, 1881-1884.
Other activities of potential interest to others

Cost UE