info@epichembio.eu + 34 986 812 316

Daniela Secci group. Organic and Pharma synthesis.

daniela.secci@uniroma1.it
dctf.uniroma1.it/dipartimento/persone/docenti/professori-associati/secci-daniela
Address
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma
Italy
Keywords

Epigenetic, HAT inhibitors, MAO inhibitors, Carbonic anhydrase inhibitors, HPLC enantioseparation

Models

Techniques

Organic synthesis, pharmaceutical synthesis, biotechnologies.

Collaborations outside COST

- Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, di Baltimora - “Departamento de Farmacología”, University of Santiago de Compostela (Spain) - Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, South Africa. - Laboratorio di Chemioterapia Sperimentale - Istituto Regina Elena di Roma

Short description of ongoing research projects

1. Development of dual HAT/HDAC modulators based on the chalcone scaffold 2. Production of the Mab Rituximab from genetically modified rice 3. Development of selective MAO-B inhibitors based on the thiazol-2- yl)hydrazine scaffold 4. Development of secondary sulfonamides based on the open saccharin scaffold as selective inhibitors of different isoforms of human carbonic anhydrase.

Publications
  1. D'Ascenzio, M., Guglielmi, P., Carradori, S., Secci, D., Florio, R., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Supuran, C.T. Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms (2017) Journal of enzyme inhibition and medicinal chemistry, 32 (1), pp. 51-59.
  2. Pierini, M., Carradori, S., Menta, S., Secci, D., Cirilli, R. 3-Phenyl-4-oxy-5-phenyl-4,5-dihydro-1H-pyrazole: A fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethylphenylcarbamate) chiral stationary phase. (2017) Journal of Chromatography A, 1499, pp. 140-148
  3. Di Martile, M., Desideri, M., De Luca, T., Gabellini, C., Buglioni, S., Eramo, A., Sette, G., Milella, M., Rotili, D., Mai, A., Carradori, S., Secci, D., De Maria, R., Del Bufalo, D., Trisciuoglio, D. Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stemlike cells (2016) Oncotarget, 7 (10), pp. 11332-11348
  4. De Monte, C., Carradori, S., Secci, D., D'Ascenzio, M., Guglielmi, P., Mollica, A., Morrone, S., Scarpa, S., Aglianò, A.M., Giantulli, S., Silvestri, I. Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of rostate cancer and melanoma (2015) European Journal of Medicinal Chemistry, 105, pp. 245-262.
  5. De Monte, C., Carradori, S., Chimenti, P., Secci, D., Mannina, L., Alcaro, F., Petzer, A., N'Da, C.I., Gidaro, M.C., Costa, G., Alcaro, S., Petzer, J.P. New insights into the biological properties of Crocus sativus L.: Chemical modifications, human monoamine oxidases inhibition and molecular modeling studies (2014) European Journal of Medicinal Chemistry, 82, pp. 164-171.
Other activities of potential interest to others

Plant Molecular Farming for the production of biologicals from genetically modified plants.


Cost UE