Address
Universidad de Vigo, Facultad de Quimica. Quimica Organica. Campus Lagoas Marcosende, 36310, Vigo, (SPAIN)SpainKeywords
Natural products, total synthesis, modulators, KMT, HDM
Models
Stereoselective synthesis, structure elucidation
Techniques
Organic synthesis; lab automation
Collaborations outside COST
Dr. Hinrich Gronemeyer
Research Director (DRCE) I.N.S.E.R.M., IGBMC
67404 Illkirch Cedex, BP10142 France
Tel: +(33) 388 65 3473
Fax: +(33) 388 65 3437
Email: hg@igbmc.fr
Short description of ongoing research projects
Design and synthesis of epigenetic modulators based on the structure of natural products: focus on psammaplin A/bisaprasin, chaetocin/chetomin, nahuoic acid and tripartin
Publications
- Synthesis of 7-Alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-Alkylidene-Paullones) by N-cyclization-Oxidative Heck Cascade and Characterization as Sirtuin Modulators. J. G. Denis, G. Franci, L. Altucci, J. M. Aurrecoechea, A. R. de Lera, and R. Álvarez. Organic & Biomolecular Chemistry, 2015, 13, 2800-2810.
- Novel Symmetrical Ureas as Modulators of Protein Arginine Methyl Transferases
Noelia Fontán, Patricia García-Domínguez, Rosana Álvarez, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2013; 21 ( 7) 2056–2067
- A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures. Garcia-Dominguez, Patricia; Weiss, Melanie; Lepore, Ilaria; Alvarez, Rosana; Altucci, Lucia; Gronemeyer, Hinrich; de Lera, Angel R. ChemMedChem 2012. 7 (12) 2101–2112.
- Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities. Pereira, Raquel; Benedetti, Rosaria; Perez-Rodriguez, Santiago; Nebbioso, Angela; Garcia-Rodriguez, Jose; Carafa, Vincenzo; Stuhldreier, Mayra; Conte, Mariarosaria; Rodriguez-Barrios, Fatima; Stunnenberg, Hendrik G.; Gronemeyer, Hinrich; Altucci, Lucia; de Lera, Angel R. Journal of Medicinal Chemistry (2012), 55(22), 9467-9491
- Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008. Nebbioso A.; Pereira R, Khanwalkar H, Matarese F, Garcia-Rodriguez J, Miceli M, Logie C, Kedinger V, Ferrara F, Stunnenberg HG, de Lera AR, Gronemeyer H, Altucci L. Molecular Cancer Therapeutics 2011, 10, 2394-2404
Other activities of potential interest to others
Member of the Editorial Board of ChemMedChem