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Peter Kele Group. Chemical Biology

kele.peter@ttk.mta.hu
chembiol.ttk.mta.hu
Address
Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körújta 2., 1117, Budapest, Hungary
Hungary
Keywords

fluorescent labels, bioorthogonal, click chemistry, fluorogenic labels, bioorthogonalized amino acids and nucleotides

Models

synthetic organic chemistry

Techniques

synthetic organic chemistry

Collaborations outside COST

EMBL, Heidelberg, Germany (Edward Lemke) KIT, Karlsruhe, Germany (Hans-Achim Wagenknecht) ENS, Paris, France (Shixin Ye-Lehmann)

Short description of ongoing research projects

-Design and synthesis of fluorescent/fluorogenic probes for bioorthogonal labeling of proteins and nucleic acids -Synthesis of bioorthogonalized (tetrazine, cyclooctynes, trans-cyclooctene, azide-modified) building blocks (amino acids, nucleotides) -Synthesis of reagents for the selective modification of rare amino acids (Cys, Tyr) -Genetic encoding of bioorthogonalized amino acids into proteins

Publications
  1. Herner, A.; Girona, G. E.; Nikić, I.; Kállay, M.; Lemke, E. A.; Kele, P., New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts, Bioconjugate Chem. 2014, 25(7), 1370-1374.
  2. Cserép, G. B.; Baranyai, Zs.; Komáromy, D.; Horváti, K.; Bősze, Sz.; Kele, P., Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags, Tetrahedron 2014, 70, 5961-5965.
  3. Stubinitzky, C.; Cserép, G. B.; Bätzner, E.; Kele, P.; Wagenknecht, H-A., 2’-Deoxyuridine Conjugated with a Reactive Monobenzocyclooctyne as a DNA Building Block for Copper-Free Click-type Postsynthetic Modification of DNA, Chem. Commun. 2014, 50, 11218-11221.
  4. Huber, M. C.; Schreiber, A.; von Olshausen, P.; Varga, B. R.; Kretz, O.; Joch, B.; Barnert, S.; Schubert, R.; Eimer, S.; Kele, P.; Schiller, S. M., Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments, Nat. Mater. 2015, 14, 125-132.
  5. Cserép, G. B.; Demeter, O.; Bätzner, E.; Kállay, M.; Wagenknecht, H-A.; Kele, P., Synthesis and Evaluation of Nicotinic Acid Derived Tetrazines for Bioorthogonal Labeling, Synthesis 2015, doi: 10.1055/s-0034-1380721.
Other activities of potential interest to others


Cost UE