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Andrea Mattevi Group: Structural Biology
Department of Biology and Biotechnology, University of Pavia. Via Ferrata, 9 I-27100 PAVIA (Italy)

Histone methylation, chromatin-modifying enzymes, epidrug, cancer, structural biology


Biochemical, biophysical, and structural studies of protein complexes


X-ray crystallography, SAXS, spectroscopy, binding methods, protein expression in different hosts, computational chemistry

Collaborations outside COST

My lab collaborates with the Austrian Center for Industrial Biotechnology and biotech-pharma industries. My group is involved in an international research consortium (as WP member) of a European project H2020 project on biocatalysis.

Short description of ongoing research projects

Our approach is intended to deliver proof-of-principle data that document the feasibility and validity of designing and developing small-molecule epi-drugs which target non-active site/non-catalytic domains in the context of the multiple roles of chromatin enzymes in cell transformation.

  1. • Pilotto, S., Speranzini, V., Tortorici, M., Durand, D., Fish, A., Valente, S., Forneris, F. , Mai, A., Sixma T.K., Vachette, P., Mattevi*, A. (2015) Interplay between nucleosomal DNA, histone tails and CoREST underlies LSD1-mediated H3 demethylation Proc. Natl. Acad. Sci. USA 112, 2752-2757
  2. • Barrios, A.P., Gómez, A.G., Sáez, J.E., Ciossani, G., Toffolo, E., Battaglioli, E., Mattevi*, A., Andres, M.E. (2014) Differential properties of transcriptional complexes formed by the CoREST family. Mol. Cell. Biol. 34, 142760-142770
  3. • Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani G., Vellore, N.A., Bailey, S.G., Cowan, J., O’Connell, M., Crabb, S.J., Packham, G., Mai, A., Baron, R., Ganesan, A., Mattevi*, A. (2013) Protein recognition by small peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS Chem. Biol. 8, 1677-1682
  4. • Nenci, S., Piano, V., Rosati, S., Alverti, A., Pandini, V., Fraaije, M.W., Heck, A.J.R., Edmondson, D.E., Mattevi*, A. (2012) The precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis. Proc. Natl. Acad. Sci. USA, 109, 18791-18796
  5. • Chaiyen, P., Fraaije, M.W., Mattevi*, A. (2012) The enigmatic reaction of flavins with oxygen. Trends Biochem. Sci. 37, 373-380
Other activities of potential interest to others

Editorial Advisory Board of FEBS J, Acta Crystallographica F.

Cost UE