info@epichembio.eu + 34 986 812 316

Cell Architecture.

lehotzky.attila@ttk.mta.hu
www.ttk.mta.hu/en/?s=lehotzky
Address
Hungarian Academy of Sciences 1117 Budapest, Magyar tudósok körútja 2. 1519 Budapest, P.O. Box 286
Hungary
Keywords

microtubules, acetylation, microfilaments, immunofluorescence, immunoblotting

Models

CG-4 based oligodendrocyte differentiation, TPPP-expressing CHO TeT-On cells, cellular model systems

Techniques

western blotting, ICC, confocal and epifluorescent microscopy, fluorescent protein conjugation and eukaryotic expression

Collaborations outside COST

no active actually, or all within Cost.

Short description of ongoing research projects

Over ten years of pharmaceutical industry, now over ten years in science and academy. Hands-on practice still is working on different fields, i am rather expert than a boss.

Publications
  1. Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12.
  2. Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J. Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome. Biochim Biophys Acta. 2015 Jan;1852(1):83-91.
  3. Oláh J, Tőkési N, Lehotzky A, Orosz F, Ovádi J. Moonlighting microtubule-associated proteins: regulatory functions by day and pathological functions at night. Cytoskeleton (Hoboken). 2013 Nov;70(11):677-85.
  4. Tokési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P, Ovádi J. TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. J Biol Chem. 2010 Jun 4;285(23):17896-906.
  5. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia. 2010 Jan 15;58(2):157-68.
Other activities of potential interest to others

RNAi techniques, mostly plasmid and siRNA based.


Cost UE