Mass spectrometry, metabolites, small molecules
Leishmania infantum, Vitis vinifera, fungus, several samples (ex. teas and organic samples)
Gas Chromatography/Mass Spectrometry, Liquid Chromatography/Mass Spectrometry, Fourier Transform Ion Cyclotron Resonance/Mass Spectrometry
The GEMAB group has collaborations with Magda Claeys´s at Atwerpen Universiteit and Jaap Boon at Jaap Enterprises. The main goal of this group is to explore the potentialities of advanced mass spectrometry to investigate at molecular level, the structure, and the reactivity of compounds with environmental and biological interest. The Enzymology group has several collaborations with Neil Kelleher’s at Northwestern University, Peter Roepstorff’s at Southern Denmark University, Roman Zubarev’s at Karolinska Institute and Albert Heck’s at Bijvoet Center. The mission of this group is to unravel enzyme function and structure, exploring the exquisite complexity of life through a systems biology approach. Both groups also collaborate with some pharmaceutical industries and other groups in Universidade de Lisboa.
The projects consist in the identification of metabolites using ultra-high resolution and high-mass accuracy provided by FTICR-MS. The models used for these projects are Human visceral leishmaniasis (an important public health problem) and grapevine downy-mildew (a major economical concern). The metabolites identified will allow to build a network of metabolic pathways that will reveal the pathways and the mechanisms responsible for the infection and the key metabolites associated with resistance and survival.
Team member of the Rede Nacional de Espectrometria de Massa.