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Epigenetics. Renal and cardiometabolic risk
Instituto de Investigación Sanitaria INCLIVA, Avda. Menéndez Pelayo 4 acc. 46010 Valencia

Environmental exposure to metals, cardiovascular risk, DNA methylation, DNA hydroxymethylation and epidemiologic studies


Environmental exposure to metals, cardiovascular risk, DNA methylation, DNA hydroxymethylation and epidemiologic studies


- Design of epidemiologic studies. Pre-processing methods of raw Illumina Infinium 450K data for evaluating DNA methylation and hydroxymethylation in paired arrays. - Statistical methods to address confounding and gene-environment-epigenome interaction. - Causal inference statistical methods for the assessment of mediation in epidemiologic studies. - Simulation methods including jack-knife, bootstrap, permutation and MCMC approaches for statistical replication of results in the absence of external population for cross-validation.

Collaborations outside COST

I hold an Adjunct Assistant Professor appointment in the Department of Environmental Health Sciences at Johns Hopkins Bloomberg School of Public Health (Baltimore, US). In addition I keep active collaborations with renowned scientists in the field of cardiovascular, environmental, genetic and epigenetic epidemiology from institutions including the Johns Hopkins Medical Institutions, Texas Biomedical Research Institute and MedStar Research Institute (US), Graz University (Austria), Queen Mary University of London (UK), University of Tartu (Estonia) and others.

Short description of ongoing research projects

My lines of research are on environmental epigenetics and cardiovascular risk. I am the principal investigator (PI) of two projects funded by the Spanish Funds for Research, which evaluate the role of exposure to metals and genetic and epigenetic variation (including both DNA methylation and hydroxymethylation) on cardiovascular risk and atherosclerosis.

  1. Ruiz-Hernandez A, Kuo C, Rentero-Garrido P, Tang W, Redon J, Ordovas JM, Navas-Acien A and Tellez-Plaza M. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Clinical Epigenetics 2015, 7:55 doi:10.1186/s13148-015-0055-7
  2. Tellez-Plaza M, et al. Association of Global DNA Methylation and Global DNA Hydroxymethylation with Metals and other Exposures in Human Blood DNA Samples. Environmental Health Perspectives 2014 Sep;122(9):946-54
  3. Galan-Chilet I, Guallar E, Martin-Escudero JC, De Marco G, Dominguez-Lucas A, Gonzalez-Manzano I, Lopez-Izquierdo R, Redon J, Chaves FJ, Tellez-Plaza M. Do genes modify the association of selenium and lipid levels? Antioxid Redox Signal. 2015 May 20;22(15):1352-62
  4. Tellez-Plaza M, et al. Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine. Environ Health Perspect. 2013 Mar;121(3):345-51
  5. 5. Tellez-Plaza M, et al. Cadmium Exposure and Incident Cardiovascular Disease: A Prospective Cohort Study. Epidemiology. 2013 May;24(3):421-9.
Other activities of potential interest to others

Cost UE