info@epichembio.eu + 34 986 812 316

Ganesan. Organic Synthesis.

a.ganesan@uea.ac.uk
www.uea.ac.uk/pha/ganesan
Address
School of Pharmacy, University of East Anglia. Norwich Research Park, Norwich, Norfolk, NR4 7TJ, UK
United Kingdom
Keywords

epigenetics; medicinal chemistry; chemical biology; natural products; organic synthesis

Models

in vitro mechanism-based and cell-based assays

Techniques

medicinal chemistry and chemical biology

Collaborations outside COST

1) A-ParaDDisE FP7 consortium 2) with Flavio Emery, Faculty of Pharmacy, University of Sao Paulo, Brazil

Short description of ongoing research projects

1) Modulation of epigenetic acylation: Inhibitors of HATS, HDACs and sirtuins 2) Modulators of epigenetic methylation: Inhibitors of DNMTs and LSD1 3) Epigenetic activation of biosynthetic pathways 4) Total synthesis of biologically active natural products 5) Antimicrobial drug discovery

Publications
  1. Malcomson, T.; Yelekci, K.; Borrello, M. T.; Ganesan, A.; Semina, E.; de Kimpe, N.; Mangelinckx, S.; Ramsay, R. R. cis-Cyclopropylamines as Mechanism-based Inhibitors of Monoamine Oxidases. FEBS J. 2015, 282, 3190-3198.
  2. Masuda, Y.; Tanaka, R.; Kai, K.; Ganesan, A.; Doi, T. Total Synthesis and Biological Evaluation of PF1171A, C, F, and G, Cyclic Hexapeptides with Insecticidal Activity. J. Org. Chem. 2014, 79, 7844-7853.
  3. Tortorici, M.; Borrello, M. T.; Tardugno, M.; Chiarelli, L. R.; Pilotto, S.; Ciossani, G.; Vellore, N. A.; Bailey, S. G.; Cowan, J.; O’Connell, M.; Crabb, S. J.; Packham, G.; Mai, A.; Baron, R.; Ganesan, A.; Mattevi, A. Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. ACS Chem. Biol. 2013, 8, 1677-1682.
  4. Davies, E. R.; Haitchi, H. M.; Thatcher, T. H.; Sime, P. J.; Kottmann, R. M.; Ganesan, A.; Packham, G.; O'Reilly, K. M. A. Davies, D. E. Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis. Am. J. Resp. Cell Mol. Biol. 2012, 46, 687-694.
  5. Benelkebir, H.; Donlevy, A. M.; Packham, G.; Ganesan, A. Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor. Org. Lett. 2011, 13, 6334-6337.
Other activities of potential interest to others


Cost UE