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Viktor Víglaský group. Structure Analysis of Biomacromolecules
Pavol Jozef Safarik University, Faculty of Sciences, Institute of Chemistry, Moyzesova 11, Kosice

Alternative non B-DNA structure, G-quadruplex, structure, stability, ligand


Influence of alternative DNA structural motifs on gene expression


various electrophoreses, circular dichroism, absorption and fluorescent spectroscopies

Collaborations outside COST

University of Ljublana and NMR centre, Slovenia (prof. Janez Plavec) Comenius University, Slovakia (prof. Tibor Hianik) Helmholtz Centre for Environmental Research, Germany (Dr.Beate Strehlitz)

Short description of ongoing research projects

Structural stability of natural and aptameric non B-DNA structural motifs, focus on G-quadruplexes and cruciforms. Goals: i) their potential for applying in nanodevices, ii) they are promising target for anticancer drugs.

  1. Tóthová P, Krafčíková P, Víglaský V. Formation of Highly Ordered Multimers in G-Quadruplexes. Biochemistry 2014, 53,7013-27. doi: 10.1021/bi500773c.
  2. Tlučková K, Marušič M, Tóthová P, Bauer L, Šket P, Plavec J, Viglasky V. Human papillomavirus G-quadruplexes. Biochemistry 2013, 52, 7207-16. doi: 10.1021/bi400897g.
  3. Marusic M, Sket P, Bauer L, Viglasky V, Plavec J. Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops. Nucleic Acids Res. 2012 40, 6946-56. doi: 10.1093/nar/gks329.
  4. Bauer L, Tlučková K, Tóhová P, Viglaský V. G-quadruplex motifs arranged in tandem occurring in telomeric repeats and the insulin-linked polymorphic region. Biochemistry 2011, 50, 7484-92. doi: 10.1021/bi2003235.
  5. Poniková S, Tlučková K, Antalík M, Víglaský V, Hianik T. The circular dichroism and differential scanning calorimetry study of the properties of DNA aptamer dimers. Biophys Chem. 2011,155, 29-35. doi: 10.1016/j.bpc.2011.02.004.
Other activities of potential interest to others

TGGE - Temperature-gradient gel electrophoresis is a specific method routinely used in our laboratory.

Cost UE