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Epigenomics. Epigenetic Reprogramming
Rudjer Boskovic Institute, Bijenicka cesta 54, 10 000 Zagreb, Croatia

cancer, epigenetics, natural compounds, oncometabolic


human (cell cultures and native human samples - head and neck tumors)


classic molecular biology techniques

Collaborations outside COST

with Prof. Young-Joon Surh, Ph.D., Seoul National University

Short description of ongoing research projects

Role of PKC-delta and RelA in development of drug resistance, PKM2 and response to cancer therapy

  1. Pyridine nucleotides in regulation of cell death and survival by redox and non-redox reactions. Novak Kujundžić R, Žarković N, Gall Trošelj K. Crit Rev Eukaryot Gene Expr. 2014;24(4):287-309. Review.
  2. Selected attributes of polyphenols in targeting oxidative stress in cancer. Stepanic V, Gasparovic AC, Troselj KG, Amic D, Zarkovic N. Curr Top Med Chem. 2015;15(5):496-509.
  3. Curcumin in combined cancer therapy. Troselj KG, Kujundzic RN. Curr Pharm Des. 2014;20(42):6682-96. Review.
  4. Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. Grbesa I, Pajares MJ, Martínez-Terroba E, Agorreta J, Mikecin AM, Larráyoz M, Idoate MA, Gall-Troselj K, Pio R, Montuenga LM. PLoS One. 2015 Apr 27;10(4):e0124670.
  5. Possible prognostic value of BORIS transcript variants ratio in laryngeal squamous cell carcinomas - a pilot study. Novak Kujundžić R, Grbeša I, Ivkić M, Krušlin B, Konjevoda P, Gall Trošelj K. Pathol Oncol Res. 2014 Jul;20(3):687-95.
Other activities of potential interest to others

I have been in charge for Human Head and Neck Tumor Tissue Bank with 600 samples (possible collaboration).

Cost UE