info@epichembio.eu + 34 986 812 316

Hansen lab (Pharm. and Med. Chemistry)

finn.hansen@uni-leipzig.de
pharmazie.biphaps.uni-leipzig.de/en/pharmaceuticalmedicinal-chemistry/
Address
Leipzig University Brüderstr. 34. 04103 Leipzig, Germany
Germany
Keywords

histone deacetylases, HDACs, HDAC inhibitors, multicomponent synthesis, rational design

Models

design and synthesis of selective histone deacetylase inhibitors

Techniques

multicomponent synthesis, conventional synthesis, solid-phase synthesis, molecular docking

Collaborations outside COST

1. Dr. Jana Held, Univesity of Tübingen, Tübingen, Germany: antiplasmodial activity of HDAC inhibitors 2. Assoc. Prof. Dr. Katherine Andrews, Griffith University, Brisbane, Australia: antiplasmodial activity of HDAC inhibitors 3. Prof. Dr. Vicky M. Avery, Griffith University, Brisbane, Australia: gametocytocidal activity of HDAC inhibitors 4. Prof. Dr. Elizabeth A. Winzeler, University of California, La Jolla, USA: Activity of HDAC inhibitors against Plasmodium liver stages 5. Prof. Dr. Holger Gohlke, Heinrich-Heine-Universität Düsseldorf, Germany: Structure-based design of HDAC inhibitors 6. Prof. Dr. Matthias U. Kassack, Heinrich-Heine-Universität Düsseldorf, Germany: Anticancer activity of HDAC inhibitors

Short description of ongoing research projects

Research interests: 1. Design and synthesis of isoform- and class-selective HDAC inhibitors 2. Development of parasite-selective antimalarial HDAC inhibitors with multistage activity 3. Multi-targeted hybrid compounds based on HDAC inhibitors 4. α-helix mimetics to inhibit protein-protein interactions 5. Membranolytic peptidomimetic foldamers as analogs of anticancer peptides (ACPs)

Publications
  1. Hansen, F. K., Sumanadasa, S. D. M., Stenzel, K., Duffy, S., Meister, S., Marek, L., Schmetter, R., Kuna, K., Hamacher, A., Mordmüller, B., Kassack, M. U., Winzeler, E. A., Avery, V. M., Andrews, K. T., Kurz, T. (2014) Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur. J. Med. Chem. 82, 204–213.
  2. Hansen, F. K., Skinner-Adams, T. S., Duffy, S., Marek, L., Sumanadasa, S. D. M., Kuna, K., Held, J., Avery, V. M., Andrews, K. T., Kurz, T. (2014) Synthesis, antimalarial properties and SAR studies of alkoxyurea-based HDAC inhibitors. ChemMedChem 9, 665–670.
  3. Diedrich, D.; Hamacher, A.; Gertzen, C. G. W.; Alves Avelar, L. A.; Reiss, G. J.; Kurz, T.; Gohlke, H.; Kassack, M. U.; Hansen, F. K. (2016) Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors. Chem. Commun. 52, 3219–3222.
  4. Diedrich, D.; Rodrigues Moita, A. J.; Rüther, A.; Frieg, B.; Reiss, G. J.; Hoeppner, A.; Kurz, T.; Gohlke, H.; Lüdeke, S.; Kassack, M. U.; Hansen, F. K. (2016) α-Aminoxy oligopeptides: synthesis, secondary structure and cytotoxicity of a novel class of anticancer foldamers. Chem. Eur. J. 22, 17600–17611
  5. Krieger, V.; Ciglia, E.; Thoma, R.; Vasylyeva, V.; Frieg, B.; de Sousa Amadeu, N.; Kurz, T.; Janiak, C.; Gohlke, H.; Hansen, F. K. (2017) α-Aminoxy Peptoids: A Unique Peptoid Backbone with a Preference for Cis-Amide Bonds. Chem. Eur. J., DOI: 10.1002/chem.201605100.
Other activities of potential interest to others

I can offer the following which I think would be of interest to the network: Techniques: multicomponent synthesis, conventional synthesis, solid-phase synthesis, microwave-assisted synthesis, molecular docking Models: Library of > 100 HDAC inhibitors Targets: Zinc-dependent histone deacetylases


Cost UE