regulation of moesin and merlin by the urokinase receptor: Model explaining distal activation of integrins by uPAR
October 27, 2017
Keywords: Urokinase receptor, Moesin, Merlin, Cell migration, Cell adhesion, Angiogenesis, siRNA
Bernard Degryse, Mishan Britto, Chun Xu Shan, Robert G.Wallace, Keith D. Rochfort, Philip M. Cummins, Gerardene Meade, Ronan P. Murphy.
Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis
This figure shows a model explaining the distal activation of integrins by uPAR. The binding of SRSRY sequence of uPAR to formyl peptide receptors such as FPRL1 (thick blue arrow) or the binding of D2A sequence located in domain 2 of uPAR to integrins (thick red arrow) initiates outside-in signalling converging towards phosphorylated moesin (P-moesin) and merlin (thin blue and thin red arrows), which results in the de-phosphorylation of moesin and phosphorylation of merlin (thick black arrow). This latter step initiates inside-out signalling (thick purple arrow) activating distal integrins (yellow arrow) that are involved in cell adhesion and migration (green arrow).