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Training School of the COST Action CM1406 on “Epigenetic Chemical Biology (EPICHEMBIO)”

October 3, 2016

Tuesday 1 st November – Friday 4 th November, Fraunhofer.

LO. Professor A. Ganesan (A.Ganesan@uea.ac.uk)

An archetypal small molecule drug discovery project requires the identification of chemical starting points that modify the functions of genes, cells, or biochemical pathways. In small molecule drug discovery, the ultimate aim is to identify new therapeutics. This is a staged process that involves the discovery of Hit compounds that are optimised to Lead and Candidate compounds using a variety of parameters and requires a multi-disciplinary team.
The focus of the COST Action CM1406 Training School will be to explore the principles underlying target identification, biochemical and cell-based assay development, small molecule screening and in-vitro ADME-Tox ultimately resulting in a Lead compound that could be optimised to a Candidate compound.

Lectures will include:

  • Introduction to epigenetic drug discovery.
  • Biochemical and cell based assay development and screening.
  • Methods to analyse in-vitro biological assay data.
  • Analysis of images from High Content Screening.
  • Cancer stem cells.

Practical work will include:

  • General concepts for biochemical and cell based assays.
  • Screening of biochemical and cell based assays against a small molecule library (proof-of-concept screen).
  • ADME-Tox assays (e.g. cell viability, apoptosis, cardiotoxicity and mitochondrial toxicity).

Other information

  • Venue: Fraunhofer-IME SP (IME-SP), Schnackenburgallee 114, 22525 Hamburg, Germany.
  • Number of trainees: 20
  • Accommodation: Some suggested options: Motel One, Kieler Straße 171, 22525, Hamburg, Tel.: +49 (0)40 89720-690, Fax.: +49 (0)40 897206-910; hamburg-altona@motel- one.com); TRYP BY WYNDHAM HAMBURG ARENA, Kieler Straße 333, 22525 Hamburg, Tel.: +49 (0)40 54740-703, Fax.: +49 (0)40 54740-100, reservations@hotel-hamburg- city.de.
  • Applications: Applicants should send a letter indicating their institute and a short abstract with their research interests to: Mr Hugh Osborne (Hugh.Osborne@uea.ac.uk).
  • Trainee grant: After confirmation of admission, trainees will be awarded a grant of 610 Euros to cover travel and living expenses. This will be sent AFTER the training school according to the rules of the COST Office, as outlined in the COST Vademecum (Part B).

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