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Department of Drug chemistry

anticancer, tumor microenvironment, drug transport, tumor models, targeting therapy


2D and 3D tumor models, antimicrobial activity testing models


3D inverse invasion assay, 3D spheroid invadopodia formation, clonogenic assay, soft agar assay, 3D Bioprinting, MTT (XTT), apoptosis/necrosis determination, confocal imaging

Collaborations outside COST

Short description of ongoing research projects

We are studying the drug penetration and activity in tumor microenvironment. We are doing experiments in tumor 2D (cell monolayers) and 3D (tumor spheroids) models, as the activity of compounds may differ a lot in those two systems. Also we study synergistic activity of chemical compounds/drugs and sonoporation influence on compound activity, make the functionalized nanoparticles for cancer targeting and study them in cell models.

  1. Janoniene A, Liu Z, Baranauskiene L, Mäkilä E, Ma M, Salonen J, Hirvonen J, Zhang H, Petrikaite V, Santos HA. A Versatile Carbonic Anhydrase IX Targeting Ligand Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging. ACS Appl Mater Interfaces. 2017 Apr 26;9(16):13976-13987. doi: 10.1021/acsami.7b04038. Epub 2017 Apr 11
  2. Kazlauskas E, Brukštus A, Petrikas H, Petrikaitė V, Čikotienė I, Matulis D. Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3-thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells. Anticancer Agents Med Chem. 2017 Feb 13. doi: 10.2174/1871520617666170213121718
  3. Zhang H, Liu D, Wang L, Liu Z, Wu R, Janoniene A, Ma M, Pan G, Baranauskienė L, Zhang L, Cui W, Matulis D, Petrikaitė V, Pan J, Zhao H, Santos HA. Microfluidic Encapsulation of Prickly Zinc-doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy. Adv Healthc Mater. 2017 Mar 8. doi: 10.1002/adhm.201601406.
  4. Liu Z, Balasubramanian V, Bhat C, Vahermo M, Mäkilä E, Kemell M, Fontana F, Janoniene A, Petrikaite V, Salonen J, Yli-Kauhaluoma J, Hirvonen J, Zhang H, Santos HA. Quercetin-based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells. Adv Healthc Mater. 2017 Feb;6(3). doi: 10.1002/adhm.201601009. Epub 2016 Dec 12
  5. Petrikaite V, Matulis D. Inhibitor Binding to Hsp90: a Review of Thermodynamic, Kinetic, Enzymatic, and Cellular Assays. Curr Prot Pept Sci. 2014 May;15(3)256-82.
Other activities of potential interest to others

Cost UE